ea0020p174 | Endocrine tumours and neoplasia | ECE2009
Dalmora Sergio Luiz
, da Silva Lucelia Magalhaes
, Zimmermann Estevan Sonego
, Lana Aline Jacobi Dalla
, Sangoi Maximiliano da Silva
, D'Avila Felipe Bianchini
The recombinant human interferon α-2a (rhIFN α-2a) is a cytokine with antiviral, antiproliferative and immunomodulatory properties, indicated for the treatment of hepatitis B and C and leukemias. The rhIFN α-2a consists of a 165166 amino acids with molecular mass of 19.5 kDa. The aim of this work was to develop and validate the reversed-phase (RP-LC) and size-exclusion (SE-LC) liquid chromatography methods for the physico-chemical characterization of rhIFN...